Patients

Will you help us to research new advanced therapies for eczema?

Will you help us to research new advanced therapies for eczema?

Eczema is very common skin affecting one in 20 UK adults. Mild eczema can usually be treated with creams and ointments but more severe eczema needs systemic treatments taken by mouth or injection. Ciclosporin is the only licensed standard treatment and methotrexate is the most commonly prescribed standard treatment in the UK.

New systemic treatments have recently been developed for eczema. Dupilumab became available on the NHS in 2019, and the first janus kinase inhibitor (JAKi) was authorised for use in 2021, but there has so far been no comparison with the standard treatments. The BEACON trial is comparing methotrexatem dupilumab and an exemplar JAKi (to be confirmed) to ciclosporin.

The trial involves 536 adults with moderate to severe eczema who need a systemic treatment. They will get either ciclosporin as an oral capsule, methotrexate self-injection, JAKi as an oral capsule or dupilumab self-injection for up to one year. The treatment they receive will be decided at random. Patients will know which treatment they have received but the trained person assessing the eczema will not know to make sure we get a truthful answer on which is best.

Patients will have between 6 and 14 check-ups at hospital over a year as per normal NHS care. The success of the different treatments will be determined by looking at participants’ skin using a reliable eczema score and by asking participants about things like itching, other symptoms and quality of life. We will collect information about side effects and also see whether the treatments offer value for money for our NHS.

We are working with the Medical Research Council to set up this trial in a way that new eczema treatments in development can be added in so we can efficiently compare them against the best treatment.

We work with eczema patients and the National Eczema Society (NES). We will make sure that we tell everyone about our results by working with our patient community, NES and the various professional networks that we belong to.

If you would like to find out more about taking part, please contact one of the recruiting centres listed below for more information. Please note, you will need to be able to attend one of the recruiting centres to participate.

To find out more about taking part in clinical trials in general, please visit the NHS website.